Spironolactone,Pharma & Personal Care grade

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CAS:52-01-7,

Spironolactone is a potassium-sparing diuretic primarily used to treat conditions such as hypertension, heart failure, and edema. It helps the body eliminate excess fluid while retaining potassium, preventing low potassium levels. Additionally, spironolactone is used to manage conditions like primary hyperaldosteronism and certain types of hormonal acne in women. It works by blocking the action of aldosterone, a hormone that can lead to sodium and water retention. Regular monitoring of kidney function and potassium levels is essential during treatment to avoid potential side effects.

CAS: 52-01-7

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Spironolactone is a medication primarily used as a diuretic (water pill) and has several important applications in clinical practice. Here are some of its main uses:

1. **Heart Failure**: Spironolactone is commonly prescribed to help manage symptoms of heart failure. It works by reducing fluid retention and improving the heart's function.

2. **Hypertension**: It can be used to treat high blood pressure, especially in cases where other medications are ineffective or contraindicated.

3. **Edema**: Spironolactone is effective in treating edema (fluid retention) associated with conditions like liver cirrhosis, nephrotic syndrome, or certain medications.

4. **Hormonal Conditions**:
- **Polycystic Ovary Syndrome (PCOS)**: It is sometimes prescribed to manage symptoms such as hirsutism (excessive hair growth) and acne.
- **Primary Hyperaldosteronism**: Spironolactone helps in treating conditions where there is excess aldosterone production, which can lead to hypertension and hypokalemia (low potassium levels).

5. **Acne and Hirsutism**: Due to its anti-androgen effects, it can be beneficial in treating acne and excessive hair growth in women.

6. **Postmenopausal Osteoporosis**: Some studies suggest it may have a role in preventing bone loss in postmenopausal women.

7. **Cushing's Syndrome**: It can be used to manage symptoms in patients with this condition, which is characterized by excessive cortisol production.

### Mechanism of Action

Spironolactone works by antagonizing aldosterone receptors in the kidneys, leading to increased sodium and water excretion while conserving potassium. This mechanism helps reduce fluid retention and lower blood pressure.

### Side Effects

Common side effects include:

- Hyperkalemia (high potassium levels)
- Gynecomastia (enlarged breast tissue in males)
- Menstrual irregularities
- Dizziness or lightheadedness
- Gastrointestinal disturbances

### Monitoring

Patients on spironolactone require regular monitoring of electrolytes, particularly potassium levels, to prevent complications from hyperkalemia.

Always consult a healthcare provider for personalized medical advice regarding spironolactone or any other medication.

More Information
SKU	52-01-7
EINECS	200-133-6
HS Code	293499
Formula	C24h32o4s
Application	Pharma & Personal Care
Color	White
Usage	Spironolactone is a potassium-sparing diuretic primarily used to treat conditions such as hypertension, heart failure, and edema. It helps the body eliminate excess fluid while retaining potassium, preventing low potassium levels. Additionally, spironolactone is used to manage conditions like primary hyperaldosteronism and certain types of hormonal acne in women. It works by blocking the action of aldosterone, a hormone that can lead to sodium and water retention. Regular monitoring of kidney function and potassium levels is essential during treatment to avoid potential side effects.